The 8 Most Significant Mental Health Studies Ever Published in the United States

It is important to look at significant studies in the field of mental health.

Significant studies in mental health also help to advance the field and contribute to the development of new therapies, interventions, and approaches to mental health care. They can also help raise awareness about mental health issues, reduce stigma, and advocate for improved mental health services and resources.

Here is a list of the most significant mental health studies published in the United States:

  1. The Diagnostic and Statistical Manual of Mental Disorders (DSM), published by the American Psychiatric Association (APA) in 1952 and regularly updated since.
  2. The Minnesota Study of Twins Reared Apart, begun in 1979, which found significant heritability for several psychiatric disorders.
  3. The National Comorbidity Survey, first conducted in the 1990s, which provided important data on the prevalence and comorbidity of mental disorders in the general population.
  4. The Brain Imaging studies in the 1990s which demonstrated structural and functional differences in the brains of people with psychiatric disorders.
  5. The Human Genome Project, completed in 2003, which has led to advances in our understanding of the genetic basis of mental illness.
  6. The Sequenced Treatment Alternatives to Relieve Depression (STAR*D) study, which began in 2006 and is one of the largest studies of treatment-resistant depression.
  7. The NIMH-funded Recovery After an Initial Schizophrenia Episode (RAISE) study, launched in 2014, which tested the effectiveness of coordinated specialty care for individuals with early psychosis.
  8. The Adolescent Brain Cognitive Development (ABCD) study, launched in 2015, which is following a large, diverse sample of children from late childhood into early adulthood to better understand brain development and risk for mental illness.


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